Commonly occurring endocrine pancreatic diseases:

Incidence is 0.4-1 per 100,000, In autopsy series, the incidence is 0-10 %, In surgical series the incidence is up to 15 % of pancreatic neoplasm. Mostly occur > 3rd decade

Insulinoma: Common symptoms are frequent attacks of low blood sugar (Hypoglycemia). This results in loss of consciousness, convulsions, headaches and palpitations in the fasting state and relieved on taking food. Patients gain weight due to overeating to avoid hypoglycemia.

Gastrinoma: The symptoms are of Suggestive of Acid peptic disease, Gastroesophageal reflux, Steatorrhea, diarrhea. Patients having Refractory, multiple, recurrent & giant ulcers (>2cm), Ulcer with diarrhea/hypercalcemia should be investigated to rule out Gastrinoma.

VIP oma: The usual symptoms are watery diarrhea (Usually > 3 L/day), hypokalemia (Low levels of potassium), hypercalcemia, hyperglycemia etc.

Glugagonoma: Skin rashes, Diabetes Mellitus, thrombophlebitis, weight loss is characteristic features.

Somatostatinoma: Presents with diarrhea, Steatorrhea, gallstones and diabetes mellitus.